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Paper Title
FORMULATION AND EVALUATION OF ALMOTRIPTAN ORAL FILM DELIVERY SYSTEM
Authors
Divya Nemani , Dr Medisetty Gayatri Devi , Dr B Nagamani , A Suneetha devi
Keywords
; oral film; buccal film; solvent casting; HPMC K4M; Eudragit
Abstract
The present study was undertaken to formulate and evaluate Almotriptan oral/buccal fast-dissolving films as a patient-friendly dosage form for migraine management. Almotriptan is a selective serotonin 5-HT1B/5-HT1D receptor agonist used in the acute treatment of migraine. Films were prepared by the solvent-casting method using Eudragit L100, HPMC K4M and HPMC K15M as film-forming polymers. Propylene glycol and Tween 80 were incorporated as plasticizer and permeation enhancer, respectively. Twelve formulations (F1–F12) were prepared by varying polymer composition. The films were evaluated for physical appearance, flatness, thickness, folding endurance, drug content, moisture uptake, moisture content and in-vitro permeation through a dialysis membrane. All formulations exhibited acceptable physical characteristics. Formulation F6, containing HPMC K4M 300 mg and Eudragit L100 60 mg, showed the highest cumulative drug release, 94.7% at 12 h. Release-kinetic analysis indicated that the Korsmeyer–Peppas model provided the best fit (R² = 0.9892), with an n value of 0.6203, suggesting non-Fickian diffusion. The developed Almotriptan buccal film system may provide a convenient alternative to conventional oral dosage forms.
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JMVRA — journal style
"FORMULATION AND EVALUATION OF ALMOTRIPTAN ORAL FILM DELIVERY SYSTEM", JMVRA - Journal of Modern and Versatile Research Approach (www.jmvra.org), ISSN:2984-8911, Vol.4, Issue 10, page no.a97-a104, October-2026, Available :https://jmvra.org/papers/JMVRA2610009.pdf
APA — 7th edition
Nemani, D., Devi, M. G., Nagamani, B., & devi, A. S. (2026). FORMULATION AND EVALUATION OF ALMOTRIPTAN ORAL FILM DELIVERY SYSTEM. Journal of Modern and Versatile Research Approach, 4(10), a97-a104. https://jmvra.org/viewpaperforall.php?paper=JMVRA2610009
MLA — 9th edition
Nemani, Divya, et al. "FORMULATION AND EVALUATION OF ALMOTRIPTAN ORAL FILM DELIVERY SYSTEM." Journal of Modern and Versatile Research Approach, vol. 4, no. 10, 2026, pp. a97-a104, https://jmvra.org/viewpaperforall.php?paper=JMVRA2610009.
Chicago — 17th, bibliography
Nemani, Divya, et al. "FORMULATION AND EVALUATION OF ALMOTRIPTAN ORAL FILM DELIVERY SYSTEM." Journal of Modern and Versatile Research Approach 4, no. 10 (2026): a97-a104. https://jmvra.org/viewpaperforall.php?paper=JMVRA2610009.
Harvard — author–date
Nemani, D. et al. (2026) 'FORMULATION AND EVALUATION OF ALMOTRIPTAN ORAL FILM DELIVERY SYSTEM', Journal of Modern and Versatile Research Approach, 4(10), pp. a97-a104. Available at: https://jmvra.org/viewpaperforall.php?paper=JMVRA2610009
IEEE — numbered reference
D. Nemani, M. G. Devi, B. Nagamani and A. S. devi, "FORMULATION AND EVALUATION OF ALMOTRIPTAN ORAL FILM DELIVERY SYSTEM," JMVRA, vol. 4, no. 10, pp. a97-a104, Oct. 2026.
Vancouver — biomedical
Nemani D, Devi MG, Nagamani B, devi AS. FORMULATION AND EVALUATION OF ALMOTRIPTAN ORAL FILM DELIVERY SYSTEM. JMVRA. 2026 Oct;4(10):a97-a104.
AMA — 11th edition
Nemani D, Devi MG, Nagamani B, devi AS. FORMULATION AND EVALUATION OF ALMOTRIPTAN ORAL FILM DELIVERY SYSTEM. JMVRA. 2026;4(10):a97-a104. Accessed at https://jmvra.org/viewpaperforall.php?paper=JMVRA2610009
BibTeX — Zotero, Mendeley, LaTeX
@article{JMVRA2610009,
author = {Divya Nemani and Medisetty Gayatri Devi and B Nagamani and A Suneetha devi},
title = {FORMULATION AND EVALUATION OF ALMOTRIPTAN ORAL FILM DELIVERY SYSTEM},
journal = {Journal of Modern and Versatile Research Approach},
volume = {4},
number = {10},
pages = {a97-a104},
year = {2026},
month = {October},
issn = {2984-8911},
url = {https://jmvra.org/viewpaperforall.php?paper=JMVRA2610009}
}
RIS — EndNote, RefWorks
TY - JOUR
AU - Nemani, Divya
AU - Devi, Medisetty Gayatri
AU - Nagamani, B
AU - devi, A Suneetha
TI - FORMULATION AND EVALUATION OF ALMOTRIPTAN ORAL FILM DELIVERY SYSTEM
T2 - Journal of Modern and Versatile Research Approach
JA - JMVRA
VL - 4
IS - 10
PY - 2026
SN - 2984-8911
UR - https://jmvra.org/viewpaperforall.php?paper=JMVRA2610009
SP - a97-a104
ER -
Issue
Volume 4 Issue 10,
October-2026
Pages : a97-a104
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