2026-11-03T23:09:58Z https://jmvra.org/oai.php

oai:jmvra.org:JMVRA2610009 2026-10-31 vol4

FORMULATION AND EVALUATION OF ALMOTRIPTAN ORAL FILM DELIVERY SYSTEM Divya Nemani Dr Medisetty Gayatri Devi Dr B Nagamani A Suneetha devi oral film buccal film solvent casting HPMC K4M Eudragit Pharmacy All The present study was undertaken to formulate and evaluate Almotriptan oral/buccal fast-dissolving films as a patient-friendly dosage form for migraine management. Almotriptan is a selective serotonin 5-HT1B/5-HT1D receptor agonist used in the acute treatment of migraine. Films were prepared by the solvent-casting method using Eudragit L100, HPMC K4M and HPMC K15M as film-forming polymers. Propylene glycol and Tween 80 were incorporated as plasticizer and permeation enhancer, respectively. Twelve formulations (F1–F12) were prepared by varying polymer composition. The films were evaluated for physical appearance, flatness, thickness, folding endurance, drug content, moisture uptake, moisture content and in-vitro permeation through a dialysis membrane. All formulations exhibited acceptable physical characteristics. Formulation F6, containing HPMC K4M 300 mg and Eudragit L100 60 mg, showed the highest cumulative drug release, 94.7% at 12 h. Release-kinetic analysis indicated that the Korsmeyer–Peppas model provided the best fit (R² = 0.9892), with an n value of 0.6203, suggesting non-Fickian diffusion. The developed Almotriptan buccal film system may provide a convenient alternative to conventional oral dosage forms. JMVRA Publication 2026-10-31 Text Journal Article info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://jmvra.org/viewpaperforall.php?paper=JMVRA2610009 https://jmvra.org/papers/JMVRA2610009.pdf Journal of Modern and Versatile Research Approach; ISSN 2984-8911; Vol. 4; Issue 10; pp. a97-a104 en https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Copyright © 2026 The Author(s). Published by JMVRA Publication under the Creative Commons Attribution 4.0 International License (CC BY 4.0).